amlodipine, Norvasc (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
GENERIC AVAILABLE: Yes
PREPARATIONS: Tablets: 2.5, 5, and 10 mg
STORAGE: Amlodipine should be stored at room temperature in a tight, light resistant container.
DOSING: The recommended starting dose of amlodipine for children and adults is 2.5 to 5 mg once daily. The maximum dose for adults is 10 mg once daily and the maximum dose for children is 5 mg once daily. Amlodipine can be taken with or without food. Amlodipine is inactivated mainly by the liver, and dosages may need to be lowered in patients with liver dysfunction.
DRUG INTERACTIONS: Combining amlodipine with sildenafil (Viagra) and similar drugs used for treating erectile dysfunction may lead to excessive reductions in blood pressure with complications, particularly fainting upon standing (orthostatic hypotension).
Ketoconazole (Nizoral, Extina, Xolegel, Kuric), itraconazole (Sporanox), ritonavir (Norvir) and other drugs that are strong inhibitors of amlodipine inactivation in the liver increase blood levels of amlodipine, resulting in excessive blood pressure reduction.
Medically Reviewed by a Doctor on 12/10/2014
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