amlodipine, Norvasc (cont.)

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PREPARATIONS: Tablets: 2.5, 5, and 10 mg

STORAGE: Amlodipine should be stored at room temperature in a tight, light resistant container.

DOSING: The recommended starting dose of amlodipine for children and adults is 2.5 to 5 mg once daily. The maximum dose for adults is 10 mg once daily and the maximum dose for children is 5 mg once daily. Amlodipine can be taken with or without food. Amlodipine is inactivated mainly by the liver, and dosages may need to be lowered in patients with liver dysfunction.

DRUG INTERACTIONS: Combining amlodipine with sildenafil (Viagra) and similar drugs used for treating erectile dysfunction may lead to excessive reductions in blood pressure with complications, particularly fainting upon standing (orthostatic hypotension).

Amlodipine significantly increases blood levels of simvastatin (Zocor). The dose of simvastatin should be limited to 20 mg daily by patients taking amlodipine.

Ketoconazole (Nizoral, Extina, Xolegel, Kuric), itraconazole (Sporanox), ritonavir (Norvir) and other drugs that are strong inhibitors of amlodipine inactivation in the liver increase blood levels of amlodipine, resulting in excessive blood pressure reduction.

Medically Reviewed by a Doctor on 12/10/2014

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