Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
GENERIC NAME: amlodipine besylate
BRAND NAME: Norvasc
DRUG CLASS AND MECHANISM: Amlodipine belongs to a class of medications called calcium channel blockers (CCBs). These medications block the transport of calcium into the smooth muscle cells lining the arteries of the heart (coronary arteries) and other arteries of the body. Since the action of calcium is important for muscle contraction, blocking calcium transport relaxes arterial muscles and expands (dilates) coronary arteries and other arteries of the body. By dilating coronary arteries, amlodipine increases the flow of blood to the heart and is useful in preventing heart pain (angina) resulting from reduced flow of blood to the heart caused by coronary artery spasm (contraction). Relaxing the muscles lining the arteries in the rest of the body lowers blood pressure, which reduces the work that the heart must do to pump blood to the body. Reducing the work of the heart also lessens the heart muscle's need for oxygen, and thereby further helps to prevent angina in patients with coronary artery disease. The FDA approved amlodipine in July 1992.
PRESCRIBED FOR: Chest pain or heart pain (angina) occurs because of insufficient oxygen delivered to the heart muscles. Insufficient oxygen may be a result of coronary artery blockage or spasm, or because of exertion which increases the need of the heart for oxygen in patients with coronary artery narrowing (coronary artery disease or atherosclerosis). Amlodipine is used for the treatment and prevention of angina resulting from coronary spasm as well as from exertion. Amlodipine also is used in the treatment of high blood pressure.
Medically Reviewed by a Doctor on 12/10/2014
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