perphenazine and amitriptyline hydrochloride (Etrafon - brand no longer available in the US) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

Perphenazine/amitriptyline should be avoided with medications like quinidine, disopyramide (Norpace), procainamide (Pronestyl), propafenone (Rhythmol), and flecainide (Tambocor) because they may also affect heart rhythm and increase the risk of an irregular heart rate and rhythm.

Perphenazine/amitriptyline should be used with caution with medications like epinephrine due to increased risk of irregular heart rates and rhythms.

PREGNANCY: Newborn babies may be at risk for withdrawal or extrapyramidal symptoms. Perphenazine/amitriptyline is not recommended for use in pregnant women.

NURSING MOTHERS: Perphenazine/amitriptyline enters breast milk and is not recommended during breastfeeding.

SIDE EFFECTS: Side effects of Perphenazine/amitriptyline are abnormal muscle contractions, difficulty breathing and swallowing, neck spasms, and movement abnormalities on face, arms, and legs. This medication also causes dizziness, drowsiness, sedation, irregular heart rate and rhythm, increase or decrease in blood pressure, and blurred vision.

Antidepressants increased the risk of suicidal thinking and behavior in short-term studies in children and adolescents with depression and other psychiatric disorders. Anyone considering the use of antidepressants in a child or adolescent must balance this risk of suicide with the clinical need. Patients who are started on therapy should be closely observed for clinical worsening, suicidal thoughts, or unusual changes in behavior.

Elderly patients with dementia related psychosis treated with antipsychotics are at an increased risk of death.


FDA Prescribing Information.

Medscape. amitriptyline/perphenazine.

Medically Reviewed by a Doctor on 8/11/2014

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