perphenazine and amitriptyline hydrochloride (Etrafon - brand no longer available in the US)

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GENERIC NAME: perphenazine and amitriptyline hydrochloride

BRAND NAME: Etrafon (no longer available in the US)

DRUG CLASS AND MECHANISM: Perphenazine/amitriptyline is a combination of an antipsychotic and an antidepressant. Perphenazine is an antipsychotic that works in the brain and nervous system. Its exact mechanism of action is unknown. Amitriptyline is a tricyclic antidepressant. It is believed that in some patients with depression, abnormal levels of neurotransmitters (chemicals that nerves use to communicate with each other) may be related to their depression. Amitriptyline elevates mood by raising the level of neurotransmitters in nerves in the brain. The FDA approved perphenazine/amitriptyline in September 1969.



PREPARATIONS: Tablets: 2/10, 2/25, 4/10, 4/25, and 4/50 mg

STORAGE: Store Perphenazine/amitriptyline tablets at room temperature between 20 C to 25 C (68 F to 77 F). Protect the drug from light.

PRESCRIBED FOR: Perphenazine/amitriptyline tablets are used in patients with moderate to severe anxiety and/or agitation and depressed mood, in patients with depression in whom anxiety and/or agitation are severe and in patients with depression and anxiety in association with chronic physical disease. Patients with schizophrenia with depressive symptoms can be considered for therapy with perphenazine/amitriptyline.

Medically Reviewed by a Doctor on 8/11/2014

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