aminophylline (Norphyl, Phyllocontin, Truphylline) injection

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

Asthma Attack Treatment

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Aminophylline is available in 25 mg/ml single-use, 10 ml (250 mg) and 20 ml (500 mg) vials and ampules.

STORAGE: Store Aminophylline between 20 C to 25 C (68 F to 77 F), protected from light.

DOSING: Dosing is based on patient's ideal body weight. In adults a loading dose of 5.7 mg/kg administered intravenously over 30 minutes followed by a continuous maintenance infusion of 0.5 mg/kg/hr for non-smokers 60 years or younger and 0.38 mg/kg/hour for those 60 years and older.

DRUG INTERACTIONS: Aminophylline (or theophylline) should not be used with drugs like cimetidine (Tagamet), erythromycin, interferons, enoxacin, thiabendazole, and tacrine (Cognex) because they slow down theophylline metabolism, leading to significantly increased theophylline levels.

Aminophylline (or theophylline) should not be used with drugs like carbamezapine, phenobarbital, and rifampin because they accelerate theophylline metabolism, leading to significantly decreased theophylline levels.

Smoking increases the breakdown of theophylline reducing theophylline blood levels.

PREGNANCY: There are no adequate studies done on aminophylline to determine safe and effective use in pregnant women.

NURSING MOTHERS: Theophylline is excreted into breast milk and may cause irritability or other signs of mild toxicity in nursing infants. Therefore, it should not be used in nursing mothers or use with extreme caution under medical supervision.

Medically reviewed by Eni Williams, PharmD

REFERENCE: Aminophylline dihydrate Prescribing Information.

Medically Reviewed by a Doctor on 12/22/2015

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