aminophylline (Norphyl, Phyllocontin, Truphylline) injection (cont.)

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DOSING: Dosing is based on patient's ideal body weight. In adults a loading dose of 5.7 mg/kg administered intravenously over 30 minutes followed by a continuous maintenance infusion of 0.5 mg/kg/hr for non-smokers 60 years or younger and 0.38 mg/kg/hour for those 60 years and older.

DRUG INTERACTIONS: Aminophylline (or theophylline) should not be used with drugs like cimetidine (Tagamet), erythromycin, interferons, enoxacin, thiabendazole, and tacrine (Cognex) because they slow down theophylline metabolism, leading to significantly increased theophylline levels.

Aminophylline (or theophylline) should not be used with drugs like carbamezapine, phenobarbital, and rifampin because they accelerate theophylline metabolism, leading to significantly decreased theophylline levels.

Smoking increases the breakdown of theophylline reducing theophylline blood levels.

PREGNANCY: There are no adequate studies done on aminophylline to determine safe and effective use in pregnant women.

NURSING MOTHERS: Theophylline is excreted into breast milk and may cause irritability or other signs of mild toxicity in nursing infants. Therefore, it should not be used in nursing mothers or use with extreme caution under medical supervision.

SIDE EFFECTS: Side effects of aminophylline are central nervous system excitement, headache, insomnia, irritability, restlessness, seizures, nausea, vomiting, diarrhea, increased urination, tremors, irregular heart rhythms, increased heart rate, and red, scaly skin.

REFERENCE: Aminophylline dihydrate Prescribing Information.

Medically Reviewed by a Doctor on 6/12/2014

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