aminophylline (Norphyl, Phyllocontin, Truphylline) injection

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GENERIC NAME: Aminophylline dihydrate injection

BRAND NAME: Norphyl, Phyllocontin, Truphylline.

DRUG CLASS AND MECHANISM: Aminophylline is a methylxanthine bronchodilator composed of theophylline (Respbid, Slo-Bid, Theo-24, Theolair) and ethylenediamine. The mechanism of action of aminophylline is not completely understood. Theophylline relaxes smooth muscle in the respiratory tract and suppresses airway stimuli. Theophylline also increases contraction of diaphragm muscles by increasing calcium uptake through chemical channels.

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Aminophylline is available in 25 mg/ml single-use, 10 ml (250 mg) and 20 ml (500 mg) vials and ampules.

STORAGE: Store Aminophylline between 20 C to 25 C (68 F to 77 F), protected from light.

PRESCRIBED FOR: Aminophylline is used for the management of acute exacerbations of asthma and chronic obstructive pulmonary disease (COPD), usually in combination with inhaled beta-2 selective agonists and oral or intravenous steroids.

DOSING: Dosing is based on patient's ideal body weight. In adults a loading dose of 5.7 mg/kg administered intravenously over 30 minutes followed by a continuous maintenance infusion of 0.5 mg/kg/hr for non-smokers 60 years or younger and 0.38 mg/kg/hour for those 60 years and older.

Medically Reviewed by a Doctor on 6/12/2014



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