GENERIC NAME: Aminophylline dihydrate injection
BRAND NAME: Norphyl, Phyllocontin, Truphylline.
DRUG CLASS AND MECHANISM: Aminophylline is a methylxanthine bronchodilator composed of theophylline (Respbid, Slo-Bid, Theo-24, Theolair) and ethylenediamine. The mechanism of action of aminophylline is not completely understood. Theophylline relaxes smooth muscle in the respiratory tract and suppresses airway stimuli. Theophylline also increases contraction of diaphragm muscles by increasing calcium uptake through chemical channels.
PRESCRIBED FOR: Aminophylline is used for the management of acute exacerbations of asthma and chronic obstructive pulmonary disease (COPD), usually in combination with inhaled beta-2 selective agonists and oral or intravenous steroids.
SIDE EFFECTS: Side effects of aminophylline are:
- central nervous system excitement,
- increased urination,
- irregular heart rhythms,
- increased heart rate, and
- scaly skin.
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