amikacin sulfate, Amikin (discontinued)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

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STORAGE: Store Amikacin at room temperature between 20 C to 25 C (68 F to 77 F).

DOSING: The recommended dose for adults, children, and older infants with normal kidney function is 15 mg/kg/day divided into 2 or 3 doses; for example, 7.5 mg/kg every 12 hours or 5 mg/kg every 8 hours.

The duration of treatment is usually 7 to 10 days.

DRUG INTERACTIONS: Amikacin should not be used with amphotericin due to significant risk of loss of hearing and severe kidney dysfunction.

Amikacin should be used with great caution with medications like furosemide (Lasix), torsemide (Demadex), cyclosporine, and tacrolimus (Prograf) due to high risk of loss of hearing and kidney dysfunction.

PREGNANCY: Amikacin is harmful to the fetus and should not be used during pregnancy unless there are not safer options.

NURSING MOTHERS: It is not known whether Amikacin enters breast milk; therefore, it is best to be cautious before using it while breastfeeding.

Medically reviewed by Eni Williams, PharmD

REFERENCE: FDA Prescribing Information

Medically Reviewed by a Doctor on 9/28/2015

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