amikacin sulfate, Amikin (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

DOSING: The recommended dose for adults, children, and older infants with normal kidney function is 15 mg/kg/day divided into 2 or 3 doses; for example, 7.5 mg/kg every 12 hours or 5 mg/kg every 8 hours.

The duration of treatment is usually 7 to 10 days.

DRUG INTERACTIONS: Amikacin should not be used with amphotericin due to significant risk of loss of hearing and severe kidney dysfunction.

Amikacin should be used with great caution with medications like furosemide (Lasix), torsemide (Demadex), cyclosporine, and tacrolimus (Prograf) due to high risk of loss of hearing and kidney dysfunction.

PREGNANCY: Amikacin is harmful to the fetus and should not be used during pregnancy unless there are not safer options.

NURSING MOTHERS: It is not known whether Amikacin enters breast milk; therefore, it is best to be cautious before using it while breastfeeding.

SIDE EFFECTS: Side effects of Amikacin are hearing loss, kidney dysfunction, loss of balance, muscular paralysis, fever, rash, headache, and low blood pressure.

Amikacin carries a boxed warning of loss of hearing and kidney dysfunction for individuals treated with high doses or for longer periods.

REFERENCE: FDA Prescribing Information


Medically Reviewed by a Doctor on 6/3/2014


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