amikacin sulfate, Amikin

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GENERIC NAME: Amikacin sulfate

BRAND NAME: Amikin

DRUG CLASS AND MECHANISM: Amikacin is a man-made aminoglycoside antibiotic. It is similar to tobramycin and gentamicin. Amikacin binds to components of bacteria that produce important bacterial proteins, blocking protein synthesis which eventually leads to stopping further bacterial growth. Amikacin is used to treat infections caused by bacteria that are resistant to gentamicin and tobramycin. Amikacin treats infections caused by gram-negative bacteria such as Pseudomonas species, Escherichia coli, Providencia species, Indole-positive and indole-negative Proteus species, Klebsiella-Enterobacter-Serratia species, and Acinetobacter. Amikacin is also used in certain staphylococcal infections as well.

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Amikacin sulfate injection is colorless solution. It is available in 50 mg/ml and 250 mg/ml strengths in 2 ml vials. It is also available in 250 mg/ml strength in 4 ml vials.

STORAGE: Store Amikacin at room temperature between 20 C to 25 C (68 F to 77 F).

PRESCRIBED FOR: Amikacin is used for serious bacterial infections like bacterial meningitis, infected burns, cystic fibrosis, and severe urinary tract infections. It used when the infecting organism is resistant to tobramycin and gentamicin.

DOSING: The recommended dose for adults, children, and older infants with normal kidney function is 15 mg/kg/day divided into 2 or 3 doses; for example, 7.5 mg/kg every 12 hours or 5 mg/kg every 8 hours.

The duration of treatment is usually 7 to 10 days.

DRUG INTERACTIONS: Amikacin should not be used with amphotericin due to significant risk of loss of hearing and severe kidney dysfunction.

Amikacin should be used with great caution with medications like furosemide (Lasix), torsemide (Demadex), cyclosporine, and tacrolimus (Prograf) due to high risk of loss of hearing and kidney dysfunction.

PREGNANCY: Amikacin is harmful to the fetus and should not be used during pregnancy unless there are not safer options.

NURSING MOTHERS: It is not known whether Amikacin enters breast milk; therefore, it is best to be cautious before using it while breastfeeding.

SIDE EFFECTS: Side effects of Amikacin are hearing loss, kidney dysfunction, loss of balance, muscular paralysis, fever, rash, headache, and low blood pressure.

Amikacin carries a boxed warning of loss of hearing and kidney dysfunction for individuals treated with high doses or for longer periods.

REFERENCE: FDA Prescribing Information


Medically Reviewed by a Doctor on 6/3/2014



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