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- What is amantadine, and how does it work (mechanism of action)?
- Is amantadine available as a generic drug?
- Do I need a prescription for amantadine?
- What are the side effects of amantadine?
- What is the dosage for amantadine?
- Which drugs or supplements interact with amantadine?
- Is amantadine safe to take if I'm pregnant or breastfeeding?
- What else should I know about amantadine?
What is the dosage for amantadine?
Amantadine is taken once or twice daily with or without food. If it causes an upset stomach, it can be taken with food. The dosage for prevention and treatment of influenza A infections in adults is 200 mg daily. For treatment of influenza, amantadine should be started within 24 to 48 hours after the onset of signs or symptoms and should be continued for 24 to 48 hours after the disappearance of signs or symptoms. To prevent influenza, amantadine should be started as soon as possible after exposure to the influenza virus and continued for at least 10 days. Persons with reduced kidney function and elderly persons may need lower doses (or less frequent doses).
The dosage for treating Parkinson's or extrapyramidal symptoms is 100 mg twice daily.
Which drugs or supplements interact with amantadine?
- The benzodiazepine class of anti-anxiety drugs, for example:
- The tricyclic class of antidepressants, for example:
- dicyclomine (Bentyl)
- Certain antihistamines, for example:
- Opiate agonists, for example:
- Certain antihypertensive medications, for example:
Since amantadine amplifies the actions of dopamine in the brain, drugs which block the effects of dopamine should be avoided in persons taking amantadine when amantadine is used for the treatment of Parkinson's disease. Such drugs include haloperidol (Haldol), metoclopramide (Reglan), and phenothiazines, for example, thioridazine (Mellaril) or triflupromazine (Stelazine).
The use of the diuretics hydrochlorothiazide or triamterene (Dyazide; Maxzide) with amantadine can reduce the kidney's ability to eliminate amantadine. This can lead to high levels of amantadine in the blood and amantadine-associated toxicity.
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