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- What is amantadine, and how does it work (mechanism of action)?
- Is amantadine available as a generic drug?
- Do I need a prescription for amantadine?
- What are the side effects of amantadine?
- What is the dosage for amantadine?
- Which drugs or supplements interact with amantadine?
- Is amantadine safe to take if I'm pregnant or breastfeeding?
- What else should I know about amantadine?
What is amantadine, and how does it work (mechanism of action)?
Amantadine is a synthetic (man-made) anti-viral drug that can inhibit the replication of viruses in cells. To prevent a viral infection, the drug should be present before exposure to the virus. Clearly, this is not practical for most viral infections. It was initially used to prevent influenza A during flu season, and, if given within 24 to 48 hours of the onset of flu symptoms, to decrease the severity of the flu. Later amantadine was found to cause improvement in the symptoms of Parkinson's disease. Amantadine's mechanism of action in Parkinson's disease is not fully understood. Its effects may be related to its ability to augment (amplify) the effects of dopamine, a neurotransmitter in the brain, that is reduced in Parkinson's disease. Amantadine is less effective than levodopa in Parkinson's disease but can offer additional benefit when taken with levodopa. Amantadine was approved by the FDA in 1966.
Is amantadine available as a generic drug?
GENERIC AVAILABLE: No
Do I need a prescription for amantadine?
What are the side effects of amantadine?
The most frequent side effects associated with amantadine that can appear after a few hours or several days of therapy include:
Less common side effects include:
- slurred speech,
- loss of appetite, and
- discolorations in the eye.
Quick Guide10 Foods to Eat When You Have the Flu in Pictures
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