altretamine, Hexalen

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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What is altretamine, and how does it work (mechanism of action)?

Altretamine is an oral drug that is used to treat ovarian cancer. The precise mechanism by which altretamine exerts its anti-cancer effect is unknown. It was approved by the FDA in 1990.

What brand names are available for altretamine?

Hexalen

Is altretamine available as a generic drug?

GENERIC AVAILABLE: No.

Do I need a prescription for altretamine?

Yes.

What are the side effects of altretamine?

Common side effects are:

What is the dosage for altretamine?

The dose of altretamine is 260 mg/square meter/day. Altretamine may be taken either for 14 or 21 consecutive days as part of one or more 28 day cycles. The total daily dose generally is split into four oral doses, one oral dose after each meal and at bedtime.

Is altretamine safe to take if I'm pregnant or breastfeeding?

It is not known whether altretamine is secreted in human milk. Since altretamine may be toxic to nursing infants, breastfeeding is not recommended during treatment with altretamine.

What else should I know about altretamine?

What preparations of altretamine are available?

Capsules of 50 mg.

How should I keep altretamine stored?

Capsules should be stored at room temperature, 15 C to 30 C (59 F to 86 F).

White blood cell counts and platelet counts may drop with altretamine treatment, increasing the risk of infection and bleeding, respectively.

Reference: FDA Prescribing Information

Last Editorial Review: 6/11/2015

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See more info: altretamine on RxList
Reviewed on 6/11/2015
References
Reference: FDA Prescribing Information

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