altretamine, Hexalen

Pharmacy Author:
Medical Editor:

GENERIC NAME: altretamine


DRUG CLASS AND MECHANISM: Altretamine is an oral drug that is used to treat ovarian cancer. The precise mechanism by which altretamine exerts its anti-cancer effect is unknown. It was approved by the FDA in 1990.



PREPARATIONS: Capsules of 50 mg.

STORAGE: Capsules should be stored at room temperature, 15 C to 30 C (59 F to 86 F).

PRESCRIBED FOR: Altretamine is used for the treatment of ovarian cancer that has persisted or has recurred following treatment with other anti-cancer drugs. Although not an approved use, altretamine also has been used for treating lung cancer.

DOSING: The dose of altretamine is 260 mg/square meter/day. Altretamine may be taken either for 14 or 21 consecutive days as part of one or more 28 day cycles. The total daily dose generally is split into four oral doses, one oral dose after each meal and at bedtime.

DRUG INTERACTIONS: Altretamine, when given to patients receiving antidepressants of the monoamine oxidase (MAO) inhibitor class (for example, phenelzine, tranylcypromine, linezolid) may cause severe orthostatic hypotension (a sudden drop in blood pressure upon standing). Combining altretamine with amitriptyline (Elavil, Endep), desipramine (Norpramin), imipramine (Tofranil, Tofranil-PM), or nortriptyline (Pamelor, Aventyl) also may increase the occurrence of orthostatic hypotension. Cimetidine (Tagamet) may reduce the elimination of altretamine from the body, increasing its blood levels and the risk of side effects. Pyridoxine (vitamin B6) may reduce the risk of neurotoxicity (see below) but may also reverse the beneficial affect of altretamine in the treatment of ovarian cancer.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Pill Finder Tool

Need help identifying pills and medications?
Use the pill identifier tool on RxList.

Back to Medications Index