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PRECAUTIONS: Before receiving alteplase, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.Before receiving this medication, tell your doctor your medical history, especially of: blood disorders (e.g., low platelets), recent childbirth, current infection, kidney problems, liver problems, recent surgery or medical procedures (e.g., biopsy, blood test).During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.Before receiving this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: "blood thinners" (e.g., warfarin), antiplatelet drugs (e.g., aspirin, clopidogrel, abciximab).Low-dose aspirin should be continued if prescribed by your doctor for specific medical reasons such as heart attack or stroke prevention (usually at dosages of 81-325 milligrams per day). Consult your doctor or pharmacist for more details.This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US National Poison Hotline at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: unusual bleeding.

NOTES: Keep all regular medical and laboratory appointments.

MISSED DOSE: Not applicable.

STORAGE: Store the unmixed vials in the refrigerator between 36-46 degrees F (2-8 degrees C) away from light. Do not freeze.After mixing, store in the refrigerator or at room temperature between 36-86 degrees F (2-30 degrees C). Use or discard within 8 hours.Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Report Problems to the Food and Drug Administration   You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088. Need help identifying pills and medications? Use the pill identifier tool on RxList.