Alpha Thalassemia (cont.)
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How Do People Inherit Alpha Thalassemia?
The inheritance of alpha thalassemia is complex. Each person inherits two alpha-globin alleles from each parent. If both parents are missing at least one alpha-globin allele, their children are at risk of having Hb Bart syndrome, HbH disease, or alpha thalassemia trait. The precise risk depends on how many alleles are missing and which combination of the HBA1 and HBA2 genes is affected.
SOURCE: Genetics Home Reference. Alpha Thalassemia.
Last Editorial Review: 8/1/2009
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