What other names is Alpha-gpc known by?

Alfa-GPC, Alpha Glycerol Phosphoryl Choline, Alpha-Glyceryl Phosphoryl Choline, Alpha-Glyceryl Phosphatidylcholine, Alpha-glycerylphosphorylcholine, Choline alphoscerate, Glycerophosphorylcholine, Glycérophosphorylcholine, GPC, GroPCho, L-A-Glyceryl Phosphorylcholine, L-alpha-glycerylphosphorylcholine.

What is Alpha-gpc?

Alpha-GPC is a chemical released when a fatty acid found in soy and other plants breaks down. It is used as medicine.

In Europe alpha-GPC is a prescription medication for the treatment of Alzheimer's disease. It is available in two forms; one is taken by mouth, and the other is given as a shot. In the United States alpha-GPC is only available as a dietary supplement, mostly in products promoted to improve memory.

Other uses for alpha-GPC include treatment of various kinds of dementia, stroke, and "mini-stroke" (transient ischemic attack, TIA). Alpha-GPC is also used for improving memory, thinking skills, and learning.

Insufficient Evidence to Rate Effectiveness for...

  • Alzheimer's disease. Developing research suggests that taking 1200 mg of alpha-GPC per day significantly improves thinking skills in Alzheimer's patients after 3 to 6 months of treatment.
  • Dementia. Giving 1000 mg of alpha-GPC per day as a shot might improve symptoms of vascular (multi-infarct) dementia including behavior, mood, and thinking skills. Researchers who did this study used a prescription-only form of alpha-GPC (Delecit) that is not available in the US.
  • Stroke and "mini-stroke" (transient ischemic attack, TIA). Stroke and TIA patients who receive alpha-GPC within 10 days after the stroke or TIA seem to have a better recovery. Early research suggests that people who get 1200 mg of alpha-GPC per day as a shot for 28 days, followed by 400 mg of alpha-GPC three times daily (1200 mg/day) by mouth for 6 months, recover more thinking skills and are better able to function.
  • Improving memory.
  • Thinking skills.
  • Learning.
  • Other conditions.
More evidence is needed to rate the effectiveness of alpha-GPC for these uses.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).

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