SIDE EFFECTS: The most common side effects of alpha-1 proteinase inhibitor are:
- hot flush, and
- increase in enzymes used to monitor liver function,
- shortness of breath,
- serious hypersensitivity-type reactions or anaphylaxis, and
- rapid heartbeat.
GENERIC AVAILABLE: No
PREPARATIONS: Alpha-1 proteinase inhibitor is available in a kit containing a single-use vial of 1000 mg alpha-1 proteinase inhibitor as a lyophilized powder, one 20 ml vial of sterile water for dilution, a transfer needle, and a filter needle.
STORAGE: Alpha-1 proteinase inhibitor should be stored below 25 C (77 F). This medicine does not require refrigeration and should not be stored in the freezer. After mixing, the solution can be kept at room temperature for administration within 3 hours.
DOSING: The recommended dose of alpha-1 proteinase inhibitor is 60 mg/kg administered into the vein (intravenously) once weekly. Alpha-1 proteinase inhibitor should be administered at a rate of up to 0.08 milliliters for each kilogram per minute. On average, each infusion takes about 15 minutes.
Patients, family members, or caregivers can be trained to administer alpha1-proteinase inhibitor at home.
DRUG INTERACTIONS: Information on drug-drug interaction is not found in the medical literature and is not provided by the manufacturer.
PREGNANCY: Alpha-1 proteinase inhibitor has not been adequately evaluated in pregnant women. Due to the lack of conclusive safety data, alpha-1 proteinase inhibitor should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus. Alpha-1 proteinase inhibitor is classified as FDA pregnancy risk category C.
NURSING MOTHERS: It is not known if alpha-1 proteinase inhibitor is excreted in breast milk. Because many drugs enter human milk and can potentially cause harm to the nursing infant, alpha-1 proteinase inhibitor should be used cautiously in nursing mothers.
REFERENCE: FDA Prescribing Information
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