alpha-1 proteinase inhibitor, Prolastin-C

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GENERIC NAME: alpha-1 proteinase inhibitor

BRAND NAME: Prolastin-C

DRUG CLASS AND MECHANISM: Alpha-1 proteinase inhibitor (Prolastin-C) is a prescription medicine used to treat alpha-1 antitrypsin (AAT) deficiency. AAT deficiency is a genetic disorder in which abnormally low levels of the protein AAT allow certain enzymes to attack healthy tissues, especially the lungs. Over time, significant lung damage occurs, and patients develop serious lung diseases like emphysema.

Alpha-1 proteinase inhibitor contains AAT donated by human subjects. AAT is derived from the plasma, the fluid part of the blood, of healthy human donors. Prolastin-C is a new formulation of Prolastin, the original alpha-1 proteinase inhibitor that has been available since 1988. Prolastin-C is a more purified and concentrated formulation that can be infused over a shorter period of time. When administered at the recommended rate, Prolastin-C can be infused in approximately 15 minutes. Additionally, unlike Prolastin, Prolastin-C does not contain prions, the infectious agent that causes mad cow disease or Creutzfeldt-Jakob disease. However, as alpha-1 proteinase inhibitor is derived from human plasma, it carries the potential risk of transmitting other infectious agents like viruses.

Medically Reviewed by a Doctor on 3/20/2015

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