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- What is alpha-1-proteinase inhibitor-injection, and how does it work (mechanism of action)?
- What brand names are available for alpha-1-proteinase inhibitor-injection?
- Is alpha-1-proteinase inhibitor-injection available as a generic drug?
- Do I need a prescription for alpha-1-proteinase inhibitor-injection?
- What are the side effects of alpha-1-proteinase inhibitor-injection?
- What is the dosage for alpha-1-proteinase inhibitor-injection?
- Which drugs or supplements interact with alpha-1-proteinase inhibitor-injection?
- Is alpha-1-proteinase inhibitor-injection safe to take if I'm pregnant or breastfeeding?
- What else should I know about alpha-1-proteinase inhibitor-injection?
What is alpha-1-proteinase inhibitor-injection, and how does it work (mechanism of action)?
Alpha-1 proteinase inhibitor (Prolastin-C) is a prescription medicine used to treat alpha-1 antitrypsin (AAT) deficiency. AAT deficiency is a genetic disorder in which abnormally low levels of the protein AAT allow certain enzymes to attack healthy tissues, especially the lungs. Over time, significant lung damage occurs, and patients develop serious lung diseases like emphysema.
Alpha-1 proteinase inhibitor contains AAT donated by human subjects. AAT is derived from the plasma, the fluid part of the blood, of healthy human donors. Prolastin-C is a new formulation of Prolastin, the original alpha-1 proteinase inhibitor that has been available since 1988. Prolastin-C is a more purified and concentrated formulation that can be infused over a shorter period of time. When administered at the recommended rate, Prolastin-C can be infused in approximately 15 minutes. Additionally, unlike Prolastin, Prolastin-C does not contain prions, the infectious agent that causes mad cow disease or Creutzfeldt-Jakob disease. However, as alpha-1 proteinase inhibitor is derived from human plasma, it carries the potential risk of transmitting other infectious agents like viruses.
There is no cure for AAT deficiency but alpha-1 proteinase inhibitor can help patients manage their condition. Alpha-1 proteinase inhibitor works in the lower respiratory tract where it inhibits neutrophil elastase (NE), the enzyme that damages lung tissue. In clinical trials, alpha-1 proteinase inhibitor therapy increased the plasma levels of AAT. The effects of augmentation therapy on lung symptoms and disease progression have yet to be proven in well-controlled clinical trials.
What brand names are available for alpha-1-proteinase inhibitor-injection?
Is alpha-1-proteinase inhibitor-injection available as a generic drug?
GENERIC AVAILABLE: No
Do I need a prescription for alpha-1-proteinase inhibitor-injection?
What are the side effects of alpha-1-proteinase inhibitor-injection?
The most common side effects of alpha-1 proteinase inhibitor are:
- hot flush, and
- increase in enzymes used to monitor liver function,
- shortness of breath,
- serious hypersensitivity-type reactions or anaphylaxis, and
- rapid heartbeat.
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