alosetron, Lotronex (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

PREGNANCY: There are no studies of alosetron in pregnant women. Therefore, it should be used cautiously during pregnancy.

NURSING MOTHERS: It is not known if alosetron is excreted in breast milk. Therefore, it should be used cautiously by nursing mothers.

SIDE EFFECTS: The most common side effect with alosetron is constipation. One-quarter to one-third of patients may develop this side effect. Severe constipation or intestinal inflammation caused by poor circulation of blood (ischemic colitis) are rare but life-threatening, may require surgery, and may cause death. Therefore, alosetron must be discontinued immediately, and immediate medical attention should be sought if constipation or the signs of ischemic colitis (rectal bleeding or a sudden worsening of abdominal pain) occur. Other less common side effects include nausea, hemorrhoids, and abdominal distention.

Reference: FDA Prescribing Information


Last Editorial Review: 3/18/2013



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