SIDE EFFECTS: Nausea, vomiting, drowsiness, and/or redness/swelling at the injection site may occur. If any of these effects persist or worsen, notify your doctor. Tell your doctor immediately if any of these serious side effects occur: change in amount of urine, skin rash, seizures, joint pain, weight loss, loss of appetite. Tell your doctor immediately if any of these unlikely but serious side effects occur: stomach pain, yellowing skin or eyes, dark urine, unusual tiredness, fever, black or bloody stool, red or pink urine, difficulty breathing, change in amount of urine. An allergic reaction to this drug is unlikely, but stop the allopurinol IV and seek immediate medical attention if it occurs. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice any other effects not listed above, contact your doctor or pharmacist.

PRECAUTIONS: Tell your doctor your medical history, especially of: kidney problems, liver problems, gout, any allergies. This drug may make you drowsy. Use caution engaging in activities requiring alertness such as driving or using machinery. Limit alcoholic beverages. Caution is advised when using this drug in the elderly because they may be more sensitive to the effects of the drug. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. This medication passes into breast milk. While there have been no reports of harm to nursing infants, consult your doctor before breast-feeding.

DRUG INTERACTIONS: Tell your doctor of all prescription and nonprescription medication you may use, especially: azathioprine, mercaptopurine, "blood thinners" (e.g., dicumarol, warfarin), penicillin antibiotics (e.g., ampicillin, amoxicillin), "water pills" (e.g., furosemide, hydrochlorothiazide), chlorpropamide, cyclosporine, probenecid, sulfinpyrazone, anti-cancer drugs. Tell your doctor if you take any drugs that cause drowsiness such as: medicine for sleep, sedatives, tranquilizers, anti- anxiety drugs (e.g., diazepam), narcotic pain relievers (e.g., codeine), psychiatric medicines (e.g., phenothiazines or tricyclics), anti-seizure drugs (e.g., carbamazepine), muscle relaxants, certain antihistamines (e.g., diphenhydramine). Check the label on all your medicines (e.g., cough-and-cold products) because they may contain drowsiness-causing ingredients. Ask your pharmacist about the safe use of these products. Do not start or stop any medicine without doctor or pharmacist approval.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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