alfuzosin, Uroxatral

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GENERIC NAME: alfuzosin

BRAND NAME: Uroxatral

DRUG CLASS AND MECHANISM: Alfuzosin belongs to a class of drugs called alpha-blockers. It is used for increasing the flow of urine that is reduced by benign prostatic hypertrophy (BPH). Alpha blockers relax the muscles in the prostate gland and the neck of the bladder. This allows the urethra (the tube that conducts urine out of the bladder) to open wider so that urine flows more easily. Other medicines in this of drugs include terazosin (Hytrin), prazosin (Minipress), doxazosin (Cardura), and tamsulosin (Flomax). Alfuzosin was approved in June 2003.

GENERIC: Yes

PRESCRIPTION: Yes

PREPARATIONS: Extended release table:, 10 mg.

STORAGE: Alfuzosin should be stored at room temperature, between 15 and 30 C (59-86 F).

PRESCRIBED FOR: Alfuzosin is used in adult men to treat slow urination due to benign prostatic hyperplasia. Most men experience an improvement in urination in 2 to 3 weeks.

DOSING: Alfuzosin is taken once daily, immediately after the same meal each day. Tablets should not be chewed or crushed.

DRUG INTERACTIONS: Alfuzosin should not be combined with ketoconazole (Nizoral, Extina, Xolegel, Kuric), itraconazole (Sporanox), or ritonavir (Norvir), because they increase alfuzosin blood levels by preventing the breakdown of alfuzosin by the liver. Combining alfuzosin with blood pressure reducing medications may increase the risk of hypotension (low blood pressure). PDE-5 inhibitors used primarily for erectile dysfunction (for example, vardenafil [Levitra, Staxyn], tadalafil [Cialis, Adcirca], and sildenafil [Viagra, Revatio]) add to the blood pressure lowering effects of alfuzosin and may result in orthostatic or postural hypotension. (See Side Effects.)




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