alendronate, Fosamax, Binosto

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

What is alendronate, and how does it work (mechanism of action)?

Alendronate is in a class of medications called bisphosphonates. The bisphosphonate class includes etidronate (Didronel), ibandronate (Boniva), pamidronate (Aredia), risedronate (Actonel), and tiludronate (Skelid). Bisphosphonates are used for treating osteoporosis (reduced density of bone that leads to fractures) and bone pain from diseases such as metastatic breast cancer, multiple myeloma, and Paget's disease. Bone is in a constant state of remodeling. New bone is laid down by cells called osteoblasts while old bone is removed by cells called osteoclasts. Bisphosphonates strengthen bone by inhibiting bone removal (resorption) by osteoclasts. After menopause, there is an increased rate of bone loss leading to osteoporosis, and alendronate has been shown to increase bone density and decrease fractures of bones. The FDA approved alendronate in September 1995.

What brand names are available for alendronate?

Fosamax, Binosto

Is alendronate available as a generic drug?

GENERIC AVAILABLE: Yes

Do I need a prescription for alendronate?

Yes

What are the uses for alendronate?

Alendronate is used for treating osteoporosis in men and postmenopausal women. It also is used for Paget's disease of bone and osteoporosis caused by steroid treatment. Non-FDA approved (off-label) uses include vitamin D overdose and osteoporosis caused by spinal injury.

What are the side effects of alendronate?

The most common side effect of alendronate is stomach pain.,

Other important side effects are:

Medically Reviewed by a Doctor on 7/15/2016

Quick GuideWhat Is Osteoporosis? Treatment, Symptoms, Medication

What Is Osteoporosis? Treatment, Symptoms, Medication
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