alemtuzumab (Campath)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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DOSING:

  • Alemtuzumab is given by intravenous infusion over 2 hours. The dose should be gradually increased to the recommended dose of 30 mg/day three times per week for 12 weeks.
  • Medications that should be given during alemtuzumab therapy to prevent side effects and infections include oral antihistamines, acetaminophen (Tylenol), trimethoprim/sulfamethoxazole DS (Bactrim DS), and famciclovir (Famvir).

DRUG CLASS AND MECHANISM:

  • Alemtuzumab is an injectable drug used for the treatment of B-cell chronic lymphocytic leukemia (B-CLL). People with CLL have too many of a type of white blood cell called lymphocytes in the blood and bone marrow. Alemtuzumab is an antibody that targets a protein called CD52 that is found on the surface of the lymphocytes. Alemtuzumab attaches to lymphocytes and then activates the immune system to help kill the lymphocytes.
  • The FDA approved alemtuzumab in May, 2001.

REFERENCE: FDA Prescribing Information

Medically Reviewed by a Doctor on 6/15/2016
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