alefacept, Amevive (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

DRUG INTERACTIONS: Alefacept suppresses the immune system. It should not be used with other drugs the also suppress the immune system because this will add to the risk of developing serious infections. Safety and efficacy of receiving live or weakened (attenuated) vaccines during alefacept treatment has not been evaluated.

PREGNANCY: Use of alefacept during pregnancy has not been evaluated.

NURSING MOTHERS: Use of alefacept by nursing mothers has not been adequately evaluated. It is not known whether alefacept is excreted in breast milk.

SIDE EFFECTS: The most common side effects of alefacept are sore throat, dizziness, cough, nausea, itching, muscle aches, chills, injection site pain and injection site redness and swelling. The most serious side effects are a reduction in the number of immune cells, liver failure, serious opportunistic infections (for example, fungal infections), cancer and allergic reactions. Alefacept should not be used by individuals whose blood lymphocyte counts are less than 250/ml.

Reference: FDA Prescribing Information

Last Editorial Review: 3/18/2013

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