alefacept, Amevive (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
SIDE EFFECTS: The most common side effects of alefacept are:
The most serious side effects are
Alefacept should not be used by individuals whose blood lymphocyte counts are less than 250/ml.
GENERIC AVAILABLE: No
PREPARATIONS: Powder for Injection: 15 mg/Vial for intramuscular use.
STORAGE: Alefacept should be stored at room temperature, 15 C to 30 C (59 C to 86 F).
DOSING: The recommended dose is 15 mg by intramuscular injection once weekly for 12 weeks. The treatment cycle can be repeated after a twelve week interval without treatment if the patient's T-lymphocyte counts are within the normal range.
DRUG INTERACTIONS: Alefacept suppresses the immune system. It should not be used with other drugs the also suppress the immune system because this will add to the risk of developing serious infections. Safety and efficacy of receiving live or weakened (attenuated) vaccines during alefacept treatment has not been evaluated.
PREGNANCY: Use of alefacept during pregnancy has not been evaluated.
NURSING MOTHERS: Use of alefacept by nursing mothers has not been adequately evaluated. It is not known whether alefacept is excreted in breast milk.
Medically reviewed by Eni Williams, PharmD
Reference: FDA Prescribing Information
Medically Reviewed by a Doctor on 6/11/2015
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