albuterol and ipratropium inhaler, Combivent, Combivent Respimat (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

PREGNANCY: There are no adequate studies of albuterol/ipratropium use during pregnancy. Some reports indicate that beta-agonists may interfere with uterine contractility.

NURSING MOTHERS: It is not known whether albuterol/ipratropium is excreted in human milk.

SIDE EFFECTS: Side effects of albuterol/ipratropium combination products are due to the component drugs. Side effects of albuterol include nervousness, tremor, headache, palpitations, fast heart rate, elevated blood pressure, nausea, dizziness, and heartburn. Throat irritation and nosebleeds also can occur. Worsening of diabetes and lowering of potassium also have been reported.

The most common side effects associated with ipratropium are dry mouth, cough, headache, nausea, dizziness, and difficulty breathing. Because of its anticholinergic effect it may worsen symptoms of benign prostatic hyperplasia, and narrow-angle glaucoma. Allergic reactions may rarely occur and may manifest as rash, hives, swelling, bronchospasm, or anaphylaxis (shock). In rare patients, albuterol/ipratropium can paradoxically precipitate life-threatening bronchospasm.

Reference: FDA Prescribing Information


Last Editorial Review: 3/14/2012



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