albumin human (Albuked-5, Albuked-25, Albuminar-5, Albuminar-25, Alburx, Albutein, Buminate) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

Children:

  • Hypovolemia: Administer albumin 25% 2.5 to 5 ml per kg of weight; repeat in 15 – 20 minutes if necessary. For patients with significant plasma deficits, use albumin 5%.
  • Hypoalbuminemia: For ages 12 to 16, administer 50 to 75 g IV as initial dose.
  • Burns: For ages 12 to 16, dose should be individualized based on plasma oncotic pressure or protein content or by direct observations of vital signs; patients must be adequately hydrated.
  • Acute respiratory distress syndrome (ARDS): For ages 12 to 16, administer 25 g of albumin IV over 30 minutes, every 8 hours for 3 days, if necessary.
  • Hemolytic Disease of the Newborn: May administer albumin 25% prior to or during exchange transfusion in a dose of 1 g per kg of bodyweight.

Safe and effective use of albumin 5% and 25% is not established in children less than 12 years of age.

DRUG INTERACTIONS: Albumin should not be diluted with sterile water because this can cause hemolysis.

Do not mix with protein hydrolysates or solutions containing alcohol since these combinations can cause the proteins to precipitate.

Do not mix with other medicinal products including blood and blood components. Albumin is compatible with whole blood, plasma, saline, glucose or sodium lactate.

PREGNANCY: There are no adequate studies done on albumin to determine safe and effective use in pregnant women.

NURSING MOTHERS: Albumin is present in breast milk. It is compatible with breastfeeding.

SIDE EFFECTS: Side effects of albumin are edema, increased heart rate, headache, nausea, vomiting, flushing, itching, fever, and chills. Allergic reactions may occur. Albumin is a blood product and therefore has a small risk of transmission of viral diseases.

REFERENCES:

FDA Prescribing Information.

Medscape. Albumin.


Medically Reviewed by a Doctor on 7/24/2014


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