albumin human (Albuked-5, Albuked-25, Albuminar-5, Albuminar-25, Alburx, Albutein, Buminate)

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GENERIC NAME: albumin human

BRAND NAME: Albuked-5, Albuked-25, Albuminar-5, Albuminar-25, Alburx, Albutein, Buminate, Flexbumin, Kedbumin, Plasbumin-5, Plasbumin-25

DRUG CLASS AND MECHANISM: Albumin is a naturally occurring transport protein found in the body. Albumin binds to many substances including bilirubin, fatty acids, hormones, enzymes, drugs, dyes, and trace elements. Albumin is responsible for 70% to 80% of the osmotic pressure of normal plasma, regulating the volume of circulating blood. Albumin temporarily increases blood volume. Commercially available albumin is fractionated from blood or plasma from donors.

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Albumin intravenous solution is available in 5% and 25% concentrations. Albumin 5% is available in 50 ml (2.5 grams of albumin), 250 ml (12.5 grams of albumin), and 500 ml (25 grams of albumin) bottles or vials. Albumin 25% is available in 20 ml (5 grams of albumin), 50 ml (12.5 grams of albumin), and 100 ml (25 grams of albumin) bottles or vials.

STORAGE: Albumin is stored at room temperature not exceeding 30 C (86 F). Do not freeze the solution.

PRESCRIBED FOR: Albumin is used for hypovolemia (low blood volume), hypoalbuminemia (low albumin), burns, acute respiratory distress syndrome (ARDS), nephrosis, renal dialysis, cardiopulmonary bypass surgery, acute liver failure, and hemolytic disease of the newborn.

DOSING:

Adults

  • Hypovolemia: Administer albumin 25% 100 to 200 ml; repeat in 15 to 20 minutes if necessary for patients' primarily needing protein/oncotic pressure. For patients with significant plasma or volume deficits (hypovolemic shock), use albumin 5%.
  • Hypoalbuminemia: Initially administer 12.5 to 25 g of albumin IV, based on total albumin deficit. Maximum 2 g of albumin per kg of weight per day.
  • Burns: After the first 24 hours, administer albumin 5% or 25% IV to achieve plasma albumin level of approximately 2.5 g / 100 ml or a total plasma protein concentration 5.2 g / 100 ml. Initial dose of 25 g of albumin is recommended.
  • Acute respiratory distress syndrome (ARDS): Administer 25 g of albumin IV over 30 minutes, every 8 hours for 3 days, if necessary.
Medically Reviewed by a Doctor on 7/24/2014



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