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Agoraphobia (cont.)

Agoraphobia At A Glance

  • Agoraphobia is defined as a fear of being outside or otherwise being in a situation from which one either cannot escape or from which escaping would be difficult or humiliating.
  • Like other phobias, agoraphobia is largely underreported, probably because many phobia sufferers find ways to avoid the situations to which they are phobic.
  • Agoraphobia often occurs in combination with panic disorder.
  • Agoraphobia occurs alone in less than 1 percent to almost 7 percent of the population.
  • There are a number of theories about what can cause agoraphobia, including a response to repeated exposure to anxiety-provoking events or a reaction to internal emotional conflicts.
  • As with other mental disorders, agoraphobia is usually caused by a number of factors, tends to run in families, and for some people, may have a clear genetic factor involved in its development.
  • Symptoms of agoraphobia include anxiety and subsequent avoidance of being in a situation in which one will have a panic attack, when in a situation from which escape is not possible, or is difficult or embarrassing.
  • The panic attacks associated with agoraphobia, like all panic attacks, may involve intense fear, disorientation, rapid heart beat, dizziness, or diarrhea.
  • The situations that are often avoided by people with agoraphobia and the environments which cause people with balance disorders to feel disoriented are sometimes quite similar, leading some cases of agoraphobia to be classified as vestibular function agoraphobia.
  • Agoraphobia tends to begin by adolescence or early adulthood.
  • Girls and women, Native Americans, middle-aged individuals, low-income populations, and individuals who are either widowed, separated, or divorced are at increased risk of developing agoraphobia.
  • Suffering from virtually any other anxiety disorder increases the risk of developing agoraphobia.
  • Symptoms of agoraphobia should be treated when the signs and symptoms of the associated anxiety are not easily, quickly, and clearly relieved.
  • Agoraphobia is often diagnosed and treated when patients seek treatment for other medical or emotional problems rather than as the primary reason that care is sought.
  • To diagnose agoraphobia, the treating psychiatrist or other physician will usually take a careful history, perform or refer to another doctor for a physical examination, and order laboratory tests as needed. Any medical condition or other emotional problem will be considered.
  • Cognitive behavioral therapy and exposure therapy are the most effective psychotherapies used to treat agoraphobia.
  • Medications like SSRIs, beta blockers, and benzodiazepines are most commonly used to treat agoraphobia. The risk of overdose, addiction, or need for increasingly higher doses make benzodiazepines a less desirable treatment for agoraphobia.
  • Agoraphobia increases the likelihood that the person will also suffer from another anxiety disorder and that both conditions will be more severe and difficult to treat.
  • Agoraphobia tends to occur more often in individuals who have a number of different physical conditions.
  • If left untreated, agoraphobia may worsen to the point where the person's life is seriously affected by the disease itself and/or by attempts to avoid or conceal it.

References:

American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Treatment Revision. Washington, D.C., 2000.

Bienvenu, O.J., Onyike, C.U., Stein, M.B., Chen, L., Samuels, J., Nestadt, G., and Eaton, W.W. Agoraphobia in adults: incidence and longitudinal relationship with panic. The British Journal of Psychiatry 188: 432-438, 2006.

Biondi, M. and Picardi, A. Increased probability of remaining in remission from panic disorder with agoraphobia after drug treatment in patients who received concurrent cognitive-behavioural therapy: a follow-up study. Psychotherapeutic Psychosomatics 72(1): 34-42, 2003.

Bruce, S.E., Vasile, R.G., Goisman, R.M., Salzman, C., Spencer, M., Machan, J.T., Keller, and M.B. Are benzodiazepines still the medication of choice for patients with panic disorder with our without agoraphobia? American Journal of Psychiatry 160: 1432-1438, August 2003.

Bruce, S.E., Yonkers, K.A., Otto, M.W., Eisen, J.L., Weisberg, R.B., Pagano, M., Shea, T., and Keller, M.B. Influence of psychiatric comorbidity on recovery and recurrence in generalized anxiety disorder, social phobia and panic disorder: a 12-year prospective study. American Journal of Psychiatry 162: 1179-1187, 2005.

Collier, D.A. FISH, flexible joints and panic: are anxiety disorders really expressions of instability in the human genome? The British Journal of Psychiatry 181: 457-459, 2002.

Fava, G.A., Ruini, C., Rafanelli, C., and Grandi, S. Cognitive behavior approach to loss of clinical effect during long-term antidepressant treatment: A pilot study. American Journal of Psychiatry 159: 2094-2095, December 2002.

Furukawa, T.A. and Watanabe, N. Psychotherapy plus antidepressant for panic disorder with or without agoraphobia. The British Journal of Psychiatry 188: 305-312, 2006.

Gersley, E. Phobias: Causes and treatments. All Psych Journal, http://www.allpsych.com, 11/17/01.

Godemann, F., Ahrens, B., Behrens, S., Berthold, R., Gandor, C., Lampe, F., and Linden, M. Classic conditioning and dysfunctional cognitions in patients with panic disorder and agoraphobia treated with an implantable cardioverter/defibrillator. Psychosomatic Medicine 63: 231-238, 2001.

Goodwin, R., Faravelli, C., Rosi, S., Cosci, F., Truglia, E., de Graaf, R., and Wittchen, H.U. The epidemiology of panic disorder and agoraphobia in Europe. European Neuropsychopharmacology 15(4): 435-443, 2003.

Grant, B.F. The epidemiology of DSM-IV panic disorder and agoraphobia in the United States: results from the national epidemiologic survey on alcohol and related conditions. Journal of Clinical Psychiatry 67(3): 363-374, 2006.

Ito, L.M., de Araujo, L.A., Tess, V.L.C., de Barros-Neto, T.P., Asbahr, F.R., and Marks, I. Self-exposure therapy for panic disorder with agoraphobia: randomized controlled study of external v. interoceptive self-exposure. The British Journal of Psychiatry 178: 331-336, 2001.

Kenwright, M., Liness, S., and Marks, I. Reducing demands on clinicians by offering computer-aided self-help for phobia/panic. The British Journal of Psychiatry 179: 456-459, 2001.

Kessler, R.C. The epidemiology of panic attacks, panic disorder and agoraphobia in the National Comorbidity Survey Replication. Archives of General Psychiatry 63(4): 415-424, 2006.

Kikuchi, M., Komuro, R., Oka, H., Kidani, T., Hanaoka, A., and Koshino, Y. Panic disorder with and without agoraphobia: comorbidity within a half-year of the onset of panic disorder. Psychiatry and Clinical Neurosciences 59(6): 639-643, 2005.

Kumano, H., Kaiya, H., Yoshiuchi, K., Yamanaka, G., Sasaki, T., and Kuboki, T. Comorbidity of irritable bowel syndrome, panic disorder and agoraphobia in a Japanese representative sample. The American Journal of Gastroenterology 99(2): 370-376, 2004.

Leinonen, E., Lepola, U., Koponen, H., Turtonen, J., Wade, A., and Lehto, H. Citalopram controls phobic symptoms in patients with panic disorder: randomized controlled trial. Journal of Psychiatry Neuroscience, 25(1): 25-32, 2000.

Magee, W.J., Eaton, W.W., Wittchen, H.U., McGonagle, K.A., and Kessler, R.C. Agoraphobia, simple phobia and social phobia in the National Comorbidity Survey. Archives of General Psychiatry 53(2): 159-168, 1996.

Milrod, B. Emptiness in agoraphobia patients. Journal of the American Psychoanalytic Association 55(3): 1007-1026, 2007.

Nascimento, I. Psychiatric disorders in asthmatic outpatients. Psychiatry Research 110(1): 73-80, 2002.

Roberge, P., Marchand, A., Reinharz, D., and Savard, P. Cognitive-behavioral treatment for panic disorder with agoraphobia: A randomized, controlled trial and cost-effectiveness analysis. Behavior Modification 32(3): 333-351, 2008.

Schuckit, M.A., and Hesselbrock, V. Alcohol dependence and anxiety disorders: what is the relationship? Focus 2: 440-453, 2004.

Shandley, K., Austin, D.W., Klein, B., Pier, C., Schattner, P., Pierce, D., and Wade, V. Therapist-assisted, internet-based treatment for panic disorder: can general practitioners achieve comparable patient outcomes to psychologists? Journal of Medical Internet Research 10(2), 2008.

Thomas, S.E., Thevos, A.K., and Randall, C.L. Alcoholics with and without social phobia: a comparison of substance use and psychiatric variables. Journal of Studies on Alcohol, vol. 60, 1999.

Wittchen, H.U., Nocon, A., Beesdo, K., Pine, D.S., Hofler, M., Lieb, R., and Gloster, A.T. Agoraphobia and panic: Prospective-longitudinal relations suggest a rethinking of diagnostic concepts. Psychotherapy and Psychosomatics 77(3), 2008.

Yardley, L., Britton, J., Lear, S., Bird, J., and Luxon, L.M. Relationship between balance system function and agoraphobic avoidance. Behavior Research Theory 33(4): 435-439, 1995.

Zimmerman, M. and Mattia, J. Principal and additional DSM-IV disorders for which outpatients seek treatment. Psychiatric Services 51:1299-1304, October 2000.


Last Editorial Review: 1/13/2009




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