adapalene, Differin

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GENERIC NAME: adapalene

BRAND NAME: Differin

DRUG CLASS AND MECHANISM: Adapalene is a gel used for the treatment of acne vulgaris (pimples). The exact mechanism of action is not known. Scientists believe that when adapalene is applied to the skin, it affects the growth of skin cells and thereby reduces the formation of pimples.

GENERIC AVAILABLE: Yes

PRESCRIPTION: Yes

PREPARATIONS: Gel, 0.1%

STORAGE: Store at room temperature, 20-25 C (68-77 F)

PRESCRIBED FOR: The topical treatment of acne vulgaris.

DOSING: Wash and dry the affected areas. Apply a thin layer of gel to the affected areas once daily at bedtime. Avoid the eyes, lips and nose. There may be a worsening of acne during the first few weeks of therapy because adapalene promotes the growth of pimples that have begun to form but are not yet visible. Therefore, treatment should not be stopped if acne appears to be worsening. Beneficial effects should be seen by 8 to 12 weeks.

DRUG INTERACTIONS: Excessive skin irritation may occur if adapalene is used with other acne medications.

PREGNANCY: Only very small amounts of adapalene are absorbed through skin and into the body. However, there are no adequate studies in pregnant women.

NURSING MOTHERS: It is not known whether adapalene is excreted in breast milk.



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