acyclovir, Zovirax

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

Acyclovir reduces the pain and the number of lesions in the initial case of genital herpes, and decreases the frequency and severity of recurrent infections.

In the treatment of shingles, acyclovir reduces pain, shortens the healing time, and limits the spread of virus and the formation of new lesions.

Acyclovir can be used to treat chickenpox and acts to reduce healing time, limit the number of lesions, and reduce fever if used within the first 24 hours after the onset of illness.

Intravenous acyclovir is used for treating herpes simplex and chickenpox in immuno-compromised patients and severe genital herpes.

Acyclovir ointment is used topically to treat initial genital herpes where it has been shown to decrease pain, reduce healing time, and limit the spread of the infection.

DOSING: Acyclovir may be taken with or without food.

  • Adult oral doses for treating genital herpes are 200 mg every 4 hours (5 times daily) for 7-10 days or 400 mg three times daily for 5-10 days.
  • Herpes Zoster (shingles) is treated with 800 mg every 4 hours (5 times daily) for 7 to 10 days.
  • The dose for treating chicken pox is 800 mg 4 times daily. The usual adult intravenous dose is 5-10 mg/kg every 8 hours for 7-10 days.

DRUG INTERACTIONS: Acyclovir may decrease levels of phenytoin (Dilantin) or valproic acid (Depakote, Depakote ER). Probenecid (Benemid) may increase acyclovir serum levels by decreasing renal excretion of acyclovir. Acyclovir may increase serum levels of theophylline (Theo-Dur, Respbid, Slo-Bid, Theo-24, Theolair, Uniphyl, Slo-Phyllin).

Medically Reviewed by a Doctor on 3/27/2015
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