Soriatane (acitretin)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

What is the dosage for Soriatane (acitretin)?

  • The recommended dose for acitretin is 25 to 50 mg daily given as a single dose with the main meal.

Which drugs or supplements interact with Soriatane (acitretin)?

  • Combining acitretin with alcohol increases the formation of etretinate. Etretinate remains in the body for a longer period than acitretin and it is very harmful to a fetus.
  • Acitretin may increase the effects of glyburide (Micronase) on blood glucose and potentially cause hypoglycemia.
  • Acitretin reduces the effect of the microdose progestin minipill. The two drugs should not be combined.
  • Acitretin should not be combined with methotrexate (Rheumatrex, Trexall) due to the increased risk of liver failure.
  • Combining tetracycline with acitretin increases intracranial pressure.
  • Taking vitamin A supplements may increase side effects of acitretin because acitretin and vitamin A have similar chemical structures.
  • If phototherapy also is being used as treatment, the doses of phototherapy should be reduced to avoid excessive burning of the skin.
Medically Reviewed by a Doctor on 11/16/2016

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