acitretin (Soriatane) (cont.)

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Medical and Pharmacy Editor:


  • Combining acitretin with alcohol increases the formation of etretinate. Etretinate remains in the body for a longer period than acitretin and it is very harmful to a fetus.
  • Acitretin may increase the effects of glyburide (Micronase) on blood glucose and potentially cause hypoglycemia.
  • Acitretin reduces the effect of the microdose progestin minipill. The two drugs should not be combined.
  • Acitretin should not be combined with methotrexate (Rheumatrex) due to the increased risk of liver failure.
  • Combining tetracycline with acitretin increases intracranial pressure.
  • Taking vitamin A supplements may increase side effects of acitretin because acitretin and vitamin A have similar chemical structures.
  • If phototherapy also is being used as treatment, the doses of phototherapy should be reduced to avoid excessive burning of the skin.


  • Acitretin is harmful to the fetus, and it must not be used during pregnancy. Women must use 2 effective forms of contraception (birth control) simultaneously for at least 1 month prior to starting acitretin therapy, during therapy, and for at least 3 years after stopping treatment.
  • Acitretin should not be used by women who are breastfeeding because acitretin can pass into breast milk and harm the infant.
Medically Reviewed by a Doctor on 6/22/2016

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