- Combining acitretin with alcohol increases the formation of etretinate. Etretinate remains in the body for a longer period than acitretin and it is very harmful to a fetus.
- Acitretin may increase the effects of glyburide (Micronase) on blood glucose and potentially cause hypoglycemia.
- Acitretin reduces the effect of the microdose progestin minipill. The two drugs should not be combined.
- Acitretin should not be combined with methotrexate (Rheumatrex) due to the increased risk of liver failure.
- Combining tetracycline with acitretin increases intracranial pressure.
- Taking vitamin A supplements may increase side effects of acitretin because acitretin and vitamin A have similar chemical structures.
- If phototherapy also is being used as treatment, the doses of phototherapy should be reduced to avoid excessive burning of the skin.
PREGNANCY AND BREASTFEEDING SAFETY:
- Acitretin is harmful to the fetus, and it must not be used during pregnancy. Women must use 2 effective forms of contraception (birth control) simultaneously for at least 1 month prior to starting acitretin therapy, during therapy, and for at least 3 years after stopping treatment.
- Acitretin should not be used by women who are breastfeeding because acitretin can pass into breast milk and harm the infant.
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