What is the dosage for Soriatane (acitretin)?
- The recommended dose for acitretin is 25 to 50 mg daily given as a single dose with the main meal.
Which drugs or supplements interact with Soriatane (acitretin)?
- Combining acitretin with alcohol increases the formation of etretinate. Etretinate remains in the body for a longer period than acitretin and it is very harmful to a fetus.
- Acitretin may increase the effects of glyburide (Micronase) on blood glucose and potentially cause hypoglycemia.
- Acitretin reduces the effect of the microdose progestin minipill. The two drugs should not be combined.
- Acitretin should not be combined with methotrexate (Rheumatrex, Trexall) due to the increased risk of liver failure.
- Combining tetracycline with acitretin increases intracranial pressure.
- Taking vitamin A supplements may increase side effects of acitretin because acitretin and vitamin A have similar chemical structures.
- If phototherapy also is being used as treatment, the doses of phototherapy should be reduced to avoid excessive burning of the skin.
Is Soriatane (acitretin) safe to use during pregnancy or while breastfeeding?
- Acitretin is harmful to the fetus, and it must not be used during pregnancy.
Women must use 2 effective forms of contraception (birth control) simultaneously
for at least 1 month prior to starting acitretin therapy, during therapy, and
for at least 3 years after stopping treatment. Major human fetal abnormalities associated with acitretin and/or etretinate include:
- Multiple synostoses
- Facial dysmorphia
- Absence of terminal phalanges
- Malformations of hip, ankle, and forearm
- Low-set ears
- High palate
- Decreased cranial volume
- Cardiovascular malformation
- And alterations of the skull and cervical vertebrae
- Acitretin should not be used by women who are breastfeeding because acitretin can pass into breast milk and harm the infant.
What else should I know about Soriatane (acitretin)?
What preparations of Soriatane (acitretin) are available?
- Capsule: 10 and 25 mg
How should I keep Soriatane (acitretin) stored?
- Acitretin should be stored between 15 C and 25 C (59 C and 77 F) and protected from light.
- Exposure to high temperatures and humidity should be avoided after the bottle is opened.
How does Soriatane (acitretin) work?
- The mechanism of action of acitretin is unknown. It is chemically related to retinoic acid and retinol (vitamin A), and it reduces skin cell production and shedding. It takes several weeks to see its effects, up to 6 months to see a full response, and psoriasis may worsen before improvement is seen.
When was Soriatane (acitretin) approved by the FDA?
- The FDA approved acitretin in October 1996.
REFERENCE: FDA Prescribing Information
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