Soriatane (acitretin)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

What is the dosage for Soriatane (acitretin)?

  • The recommended dose for acitretin is 25 to 50 mg daily given as a single dose with the main meal.

Which drugs or supplements interact with Soriatane (acitretin)?

  • Combining acitretin with alcohol increases the formation of etretinate. Etretinate remains in the body for a longer period than acitretin and it is very harmful to a fetus.
  • Acitretin may increase the effects of glyburide (Micronase) on blood glucose and potentially cause hypoglycemia.
  • Acitretin reduces the effect of the microdose progestin minipill. The two drugs should not be combined.
  • Acitretin should not be combined with methotrexate (Rheumatrex, Trexall) due to the increased risk of liver failure.
  • Combining tetracycline with acitretin increases intracranial pressure.
  • Taking vitamin A supplements may increase side effects of acitretin because acitretin and vitamin A have similar chemical structures.
  • If phototherapy also is being used as treatment, the doses of phototherapy should be reduced to avoid excessive burning of the skin.

Is Soriatane (acitretin) safe to use during pregnancy or while breastfeeding?

  • Acitretin is harmful to the fetus, and it must not be used during pregnancy. Women must use 2 effective forms of contraception (birth control) simultaneously for at least 1 month prior to starting acitretin therapy, during therapy, and for at least 3 years after stopping treatment. Major human fetal abnormalities associated with acitretin and/or etretinate include:
    • Meningomyelocele
    • Meningoencephalocele
    • Multiple synostoses
    • Facial dysmorphia
    • Syndactyly
    • Absence of terminal phalanges
    • Malformations of hip, ankle, and forearm
    • Low-set ears
    • High palate
    • Decreased cranial volume
    • Cardiovascular malformation
    • And alterations of the skull and cervical vertebrae
  • Acitretin should not be used by women who are breastfeeding because acitretin can pass into breast milk and harm the infant.

What else should I know about Soriatane (acitretin)?

What preparations of Soriatane (acitretin) are available?
  • Capsule: 10 and 25 mg
How should I keep Soriatane (acitretin) stored?
  • Acitretin should be stored between 15 C and 25 C (59 C and 77 F) and protected from light.
  • Exposure to high temperatures and humidity should be avoided after the bottle is opened.
How does Soriatane (acitretin) work?
  • The mechanism of action of acitretin is unknown. It is chemically related to retinoic acid and retinol (vitamin A), and it reduces skin cell production and shedding. It takes several weeks to see its effects, up to 6 months to see a full response, and psoriasis may worsen before improvement is seen.
When was Soriatane (acitretin) approved by the FDA?
  • The FDA approved acitretin in October 1996.

REFERENCE: FDA Prescribing Information

Medically Reviewed by a Doctor on 11/16/2016

Quick GuidePsoriasis Types, Images, Treatments

Psoriasis Types, Images, Treatments
FDA Logo

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

RxList Logo

Need help identifying pills and medications?

Use the pill identifier tool on RxList.

Subscribe to MedicineNet's Skin Care & Conditions Newsletter

By clicking Submit, I agree to the MedicineNet's Terms & Conditions & Privacy Policy and understand that I may opt out of MedicineNet's subscriptions at any time.

Health Solutions From Our Sponsors