aspirin (acetylsalicylic acid, Ecotrin)

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GENERIC NAME: aspirin

BRAND NAMES: Aspirin, Arthritis Foundation Safety Coated Aspirin, Bayer Aspirin, Bayer Children's Aspirin, Ecotrin, and many others.

DRUG CLASS AND MECHANISM: Aspirin is a nonsteroidal antiinflammatory drug (NSAID) effective in treating fever, pain, and inflammation in the body. It also prevents blood clots (i.e., is antithrombotic). As a group, NSAIDs are non-narcotic relievers of mild to moderate pain of many causes, including headaches, injury, menstrual cramps, arthritis, and other musculoskeletal conditions. Other members of this class include ibuprofen (Motrin), indomethacin (Indocin), nabumetone (Relafen) and several others. They all work by reducing the levels of prostaglandins, chemicals that are released when there is inflammation and that cause pain and fever. NSAIDs block the enzyme that makes prostaglandins (cyclooxygenase), resulting in lower concentrations of prostaglandins. As a consequence, inflammation, pain, and fever are reduced. Inhibition of prostaglandins also reduces the function of platelets and the ability of blood to clot. Aspirin, inhibits the function of platelets in a manner that is different from other NSAIDs, and its antithrombotic effects last longer than other NSAIDs. This is why aspirin is used for preventing heart attacks and strokes. The FDA approved Bayer aspirin in June 1965.




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