acetazolamide (Diamox, Diamox Sequels)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

View the Eye Diseases and Conditions Slideshow Pictures


For the treatment of glaucoma: acetazolamide should be used as an adjunct to the usual therapy.

  • The usual recommended dose for the treatment of open-angle glaucoma ranges from 250 mg to 1 gram of acetazolamide per day. Treatment with doses >1gram did not offer any additional benefits.
  • The usual recommended dose for the treatment of secondary glaucoma and for the preoperative treatment of some cases of closed-angle glaucoma is 250 mg every 4 hours. In more urgent cases, an initial dose of 500 mg followed by 125 mg or 250 mg every 4 hours as be used.

For the treatment of seizures:

  • The manufacturer's suggested total daily dose is 8-30 mg per kg in divided doses.
  • The optimum range appears to be from 375 to 1000 mg, however, some patients may respond to lower doses.
  • When used with other anti-seizure medication, the starting dose of acetazolamide should be 250 mg, and it should then gradually be increased as necessary.

For congestive heart failure:

  • To remove excess fluid in patients (diuresis) with congestive heart failure, the starting dose is usually 250 to 375 mg administered once a day in the morning.
  • As tolerance may develop with use, this medication should be skipped for a day to allow the kidneys to recover in patients who stop responding to treatment. For best diuresis, acetazolamide should be given on alternate days, or for two days followed by one day off and then repeat.

For the treatment of excess water retention caused by medication:

  • The usual recommended dose is 250 to 375 mg once a day for one or two days, alternating with a day of rest.

For acute mountain sickness:

  • The usual recommended dose is 500 mg to 1000 mg per day in divided doses.
  • 1000 mg is recommended in cases of rapid ascent.
  • Preferably, treatment should be started 24-48 hours before ascent and continued for 48 hours while at high altitude, or longer as necessary to control symptoms.
Medically Reviewed by a Doctor on 4/7/2016
Eye Conditions Quiz: Test Your IQ
FDA Logo

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

RxList Logo

Need help identifying pills and medications?

Use the pill identifier tool on RxList.

Subscribe to MedicineNet's Newsletters

Get the latest health and medical information delivered direct to your inbox!

By clicking Submit, I agree to the MedicineNet's Terms & Conditions & Privacy Policy and understand that I may opt out of MedicineNet's subscriptions at any time.

Health Solutions From Our Sponsors