Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.
For the treatment of glaucoma: acetazolamide should be used as an adjunct to
the usual therapy.
The usual recommended dose for the treatment of
open-angle glaucoma ranges
from 250 mg to 1 gram of acetazolamide per day. Treatment with doses >1gram did
not offer any additional benefits.
The usual recommended dose for the treatment of secondary glaucoma and for
the preoperative treatment of some cases of closed-angle glaucoma is 250 mg
every 4 hours. In more urgent cases, an initial dose of 500 mg followed by 125
mg or 250 mg every 4 hours as be used.
For the treatment of seizures:
The manufacturer's suggested total daily dose
is 8-30 mg per kg in divided doses.
The optimum range appears to be from 375 to
1000 mg, however, some patients may respond to lower doses.
When used with other
anti-seizure medication, the starting dose of acetazolamide should be 250 mg,
and it should then gradually be increased as necessary.
For congestive heart failure:
To remove excess fluid in patients (diuresis) with
congestive heart failure, the starting dose is usually 250 to 375 mg
administered once a day in the morning.
As tolerance may develop with use,
this medication should be skipped for a day to allow the kidneys to recover in
patients who stop responding to treatment. For best diuresis, acetazolamide
should be given on alternate days, or for two days followed by one day off and
For the treatment of excess water retention caused by medication:
recommended dose is 250 to 375 mg once a day for one or two days, alternating
with a day of rest.
For acute mountain sickness:
The usual recommended dose is 500 mg to 1000 mg per
day in divided doses.
1000 mg is recommended in cases of rapid ascent.
Preferably, treatment should be started 24-48 hours before ascent and continued
for 48 hours while at high altitude, or longer as necessary to control symptoms.