acetazolamide (Diamox, Diamox Sequels)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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POSSIBLE SERIOUS SIDE EFFECTS:

Possible serious side effects include:

PREPARATIONS:

  • Oral tablets: 125 and 250 mg
  • Oral capsules extended release (12hr): 500 mg
  • Powder for injection: 500 mg

DRUG INTERACTIONS:

  • Acetazolamide should not be used with other carbonic anhydrase inhibitors such as methazolamide (Neptazane). Use of two carbonic anhydrase inhibitors may cause dangerously low levels of blood potassium (hyponatremia).

PREGNANCY AND BREASTFEEDING SAFETY:

  • There are no adequate studies evaluating the use of acetazolamide during pregnancy. Evidence of birth defects was observed with administration of oral and injectable acetazolamide in mice, rats, hamsters, and rabbits. Therefore, acetazolamide should only be used during pregnancy if the potential benefit of treatment outweighs the potential risk to the unborn baby. Acetazolamide is classified as FDA pregnancy risk category C.
  • It is not known whether acetazolamide is excreted into human milk. Because many drugs are excreted into human milk and can cause side effects in the nursing infant, the manufacturer recommends that patients should discontinue nursing or discontinue acetazolamide, taking into account the importance of treatment to the mother. However, according to the American Academy of Pediatrics, acetazolamide is usually considered to be compatible with breast-feeding.

STORAGE:

  • All oral preparations of acetazolamide should be stored at room temperature.
  • Before mixing, injection acetazolamide should be stored at room temperature, between 20 C and 25 C (68 F and 77) F.
  • After mixing, acetazolamide injection should be stored in the refrigerator, between 2.2 C and 7.7 C (36 F and 46 F) and used within 12 hours of mixing.
Medically Reviewed by a Doctor on 4/7/2016
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