acebutolol, Sectral, Prent (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

Using epinephrine (Adrenalin, EpiPen) and beta-adrenergic blocking drugs together causes high blood pressure and a slow heartbeat since the beta-adrenergic stimulating effects of epinephrine that raise blood pressure and heart rate are exaggerated by the beta-adrenergic blocking drugs which prevent dilation of the blood vessels and increase the heart rate. To avoid this effect, it is best not to use both drugs together. If, however, both drugs are administered together, it is important to monitor blood pressure levels. Also, high blood pressure and a slow heartbeat are less likely to occur if beta-adrenergic blocking drugs that are selective for the heart such as atenolol (Tenormin) and acebutolol (Sectral) are used.

Epinephrine- and norepinephrine-depleting drugs, such as reserpine (Harmonyl), may have an additive effect when given with beta-blocking drugs and cause an abnormally slow heart beat or low blood pressure, which may give rise to dizziness or fainting.

PREGNANCY: There are no adequate studies of acebutolol in pregnant women. It should be used during pregnancy only if the potential benefit justifies the risk to the fetus

NURSING MOTHERS: Acebutolol is excreted in human milk, and use among nursing mothers is discouraged.

Medically reviewed by Eni Williams, PharmD

Reference: FDA Prescribing Information

Medically Reviewed by a Doctor on 5/28/2015

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