GENERIC NAME: acebutolol
BRAND NAME: Sectral
DRUG CLASS AND MECHANISM: Acebutolol
is a beta-adrenergic (sympathetic) blocking agent. By blocking
the action of the sympathetic nervous system on the heart, acebutolol
reduces the heart rate and the force of heart muscle contraction.
It is useful in treating high blood pressure, and abnormal heart
rhythms.
PRESCRIPTION: yes
GENERIC AVAILABLE: yes
PREPARATIONS: Capsules: 200 mg, 400 mg.
STORAGE: Capsules should
be stored at room temperature in a tightly closed container.
PRESCRIBED FOR: Acebutolol
is prescribed for patients with high blood pressure (hypertension).
It is also used in treating certain abnormal heart rhythms, such
as ventricular premature beats.
DOSING: Should be
taken before meals or at bedtime. The dosage of acebutolol should
be reduced in patients with kidney and liver dysfunction.
DRUG INTERACTIONS: Acebutolol
can aggravate breathing difficulties in patients with asthma,
chronic bronchitis, or emphysema. In patients with existing slow
heart rates (bradycardias) and heart blocks (defects in the electrical
conduction of the heart), acebutolol can cause dangerously slow
heart rates, and even shock. Acebutolol reduces the force of heart
muscle contraction and can aggravate symptoms of heart failure.
In patients with coronary artery disease, abruptly stopping acebutolol
can suddenly worsen angina, and occasionally precipitate heart
attacks. If it is necessary to discontinue acebutolol, its dosage
can be reduced gradually over several weeks. Acebutolol can mask
the early warning symptoms of low blood sugar (hypoglycemia),
and should be used with caution in patients receiving treatment
for diabetes.
PREGNANCY: Safe use of acebutolol in pregnancy and children
has not been established.
NURSING MOTHERS: The drug is excreted in human milk,
and use among nursing mothers is discouraged.
SIDE EFFECTS: Acebutolol
is generally well tolerated and side effects are mild and transient.
Rare side effects include abdominal cramps, diarrhea, constipation,
fatigue, insomnia, nausea, depression, dreaming, memory loss,
fever, impotence, lightheadedness, slow heart rate, low blood
pressure, numbness, tingling, cold extremities, sore throat, and
shortness of breath or wheezing.
Last Editorial Review: 12/31/1997
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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