abatacept, Orencia

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

Get a Grip on Rheumatoid Arthritis

SIDE EFFECTS: The most common side effects of abatacept are:

Because abatacept depresses the immune system it reduces the body's ability to fight infection. Therefore, existing infections may worsen or new ones may develop.

Other important side effects include infusion-related reactions such as:

The most serious side effects are infections and cancer.

PRESCRIPTION: Yes

GENERIC AVAILABLE: No

PREPARATIONS: Powder for Injection: 250 mg. Prefilled Syringe: 125 mg/ml.

STORAGE: Abatacept should be refrigerated between 2 C - 8 C (36 F - 46 F).

DOSING: For adult patients, abatacept is infused over 30 minutes or injected under the skin. Patients weighing < 60 kg should receive a 500 mg dose, weighing 60-100 kg a 750 mg dose and weighing >100 kg a 1000 mg dose. The initial dose of abatacept is followed by additional doses two and four weeks after the first infusion with further doses every four weeks thereafter. Alternatively, adults may receive 125 mg by subcutaneous injection one day after the initial weight-based dose and then 125 mg by subcutaneous injection once weekly.

Patients 6 to 17 years old weighing less than 75 kg should receive a 10 mg/kg infusion initially. Pediatric patients weighing more than 75 kg should receive the adult infusion doses. The initial dose of abatacept is followed by additional doses two and four weeks after the first infusion with further doses every four weeks thereafter.

Medically Reviewed by a Doctor on 4/7/2015

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