abatacept, Orencia (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

PRESCRIBED FOR: Abatacept is used alone or in combination with other DMARDs for the treatment of adult patients with moderate to severe rheumatoid arthritis. It also is used alone or combined with methotrexate (Rheumatrex, Trexall) for treating juvenile idiopathic arthritis in pediatric patients 6 years of age or older. Abatacept should not be combined with the disease-modifying TNF antagonists (for example, etanercept [Enbrel], adalimumab [Humira] and infliximab [Remicade]).

SIDE EFFECTS: The most common side effects of abatacept are:

Because abatacept depresses the immune system it reduces the body's ability to fight infection. Therefore, existing infections may worsen or new ones may develop.

Other important side effects include infusion-related reactions such as:

The most serious side effects are infections and cancer.



PREPARATIONS: Powder for Injection: 250 mg. Prefilled Syringe: 125 mg/ml.

STORAGE: Abatacept should be refrigerated between 2 C - 8 C (36 F - 46 F).

DOSING: For adult patients, abatacept is infused over 30 minutes or injected under the skin. Patients weighing < 60 kg should receive a 500 mg dose, weighing 60-100 kg a 750 mg dose and weighing >100 kg a 1000 mg dose. The initial dose of abatacept is followed by additional doses two and four weeks after the first infusion with further doses every four weeks thereafter. Alternatively, adults may receive 125 mg by subcutaneous injection one day after the initial weight-based dose and then 125 mg by subcutaneous injection once weekly.

Medically Reviewed by a Doctor on 4/7/2015

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