abatacept, Orencia (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
GENERIC AVAILABLE: No
PREPARATIONS: Powder for Injection: 250 mg. Prefilled Syringe: 125 mg/ml.
STORAGE: Abatacept should be refrigerated between 2-8 C (36-46 F).
PRESCRIBED FOR: Abatacept is used alone or in combination with other DMARDs for the treatment of adult patients with moderate to severe rheumatoid arthritis. It also is used alone or combined with methotrexate (Rheumatrex, Trexall) for treating juvenile idiopathic arthritis in pediatric patients 6 years of age or older. Abatacept should not be combined with the disease-modifying TNF antagonists (for example, etanercept [Enbrel], adalimumab [Humira] and infliximab [Remicade]).
DOSING: For adult patients, abatacept is infused over 30 minutes or injected under the skin. Patients weighing < 60 kg should receive a 500 mg dose, weighing 60-100 kg a 750 mg dose and weighing >100 kg a 1000 mg dose. The initial dose of abatacept is followed by additional doses two and four weeks after the first infusion with further doses every four weeks thereafter. Alternatively, adults may receive 125 mg by subcutaneous injection one day after the initial weight-based dose and then 125 mg by subcutaneous injection once weekly.
Patients 6 to 17 years old weighing less than 75 kg should receive a 10 mg/kg infusion initially. Pediatric patients weighing more than 75 kg should receive the adult infusion doses. The initial dose of abatacept is followed by additional doses two and four weeks after the first infusion with further doses every four weeks thereafter.
DRUG INTERACTIONS: Combining abatacept with TNF antagonists (for example, Enbrel, Humira and Remicade) increases the occurrence of infections and provides no additional relief of symptoms. Abatacept may reduce the effect of live vaccines. Live vaccines should not be given at the same time as abatacept or within three months of discontinuation of abatacept. Pediatric patients should receive all recommended immunizations prior to starting abatacept.
PREGNANCY: Abatacept has not been adequately evaluated in pregnant women.
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