abacavir, lamivudine, zidovudine, Trizivir (cont.)

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PREPARATIONS: Tablets: 300 mg abacavir/150 mg lamivudine/300 mg zidovudine.

STORAGE: Capsules and powder should be stored at room temperature, 15 C to 30 C (59 F to 86 F).

PRESCRIBED FOR: Trizivir is used alone or in combination with other anti-HIV drugs for the treatment of HIV infection.

DOSING: The recommended dose for adults and adolescents is one tablet twice daily.

DRUG INTERACTIONS: Trizivir has the same drug interactions as its component drugs, abacavir, lamivudine and zidovudine.

Alcohol competes with abacavir for elimination from the body. Therefore, alcohol consumption may increase the concentration of abacavir in the body and this could lead to increased frequency or severity of side effects from abacavir. Abacavir does not affect the elimination of alcohol.

Trimethoprim/sulfamethoxazole (Bactrim) increases the concentration of lamivudine in the body. Zalcitabine (Hivid) and lamivudine may interfere with the activity of each other.

Fluconazole (Diflucan), probenecid and trimethoprim (Trimpex) reduce the elimination of zidovudine and therefore increase the blood concentration of zidovudine. This can lead to increased side effects from zidovudine.

PREGNANCY: Trizivir has not been adequately evaluated in pregnant women.

NURSING MOTHERS: Use of Trizivir by nursing women has not been adequately studied. Nevertheless, HIV-infected mothers should not breastfeed because of the potential risk of transmitting HIV to an infant that is not infected.

SIDE EFFECTS: Trizivir causes the same side effect as its component drugs, abacavir, lamivudine and zidovudine. The most common side effects are nausea, diarrhea, vomiting, weight loss, and difficulty sleeping.

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